Zovia N IV Injection or Infusion

Zovia N IV Injection or Infusion

Generic Name: Multivitamin [water & fat soluble] + Normal Saline

Strength:

Dosage Form: IV Injection or Infusion

Manufacturer: Opsonin Pharma Ltd

Indications

Pharmacology

Dosage Information

Adults and children aged 11 years and above: 1 vial/day. The single dose vial of this preparation is reconstituted by adding 5 ml of sterile Water for injection or other intravenous fluids like 0.9% Sodium Chloride injection or 5% Glucose injection. 5 ml of diluent should be added by means of sterile syringe into the vial and gently mixed to dissolve the lyophilized powder. The entire volume of the resultant solution should then be administered by slow Intravenous injection (at least over 10 minutes) or further diluted for intravenous infusion. To minimize vitamin losses in parenteral nutrition admixtures, add the vitamins immediately prior to administration and complete administration within 24 hours.

Side Effects

Anaphylactic reactions have been reported following large intravenous doses of Thiamine. Urticaria and rash have also been associated with Zovia N. There have been very rare reports of anaphylactic reactions following IV injection/infusion with Zovia N over 1-4 minutes.

Precautions

Anaphylactic reactions may occur in allergic subjects who are susceptible to Thiamine (Vitamin B1) and nicotinamide components of Zovia N. Mild allergic reactions such as sneezing or mild asthma are warning signs that further injection/infusion may give rise to anaphylactic shock. Due to glychocolic acid content, repeated and prolonged administration in patients with jaundice of hepatic origin or severe biochemical evidence of cholestatis requires careful monitoring of liver function. Also in the case of impaired kidney function, fat-soluble vitamin levels should be carefully monitored.

Adults and children aged 11 years and above: 1 vial/day. The single dose vial of this preparation is reconstituted by adding 5 ml of sterile Water for injection or other intravenous fluids like 0.9% Sodium Chloride injection or 5% Glucose injection. 5 ml of diluent should be added by means of sterile syringe into the vial and gently mixed to dissolve the lyophilized powder. The entire volume of the resultant solution should then be administered by slow Intravenous injection (at least over 10 minutes) or further diluted for intravenous infusion. To minimize vitamin losses in parenteral nutrition admixtures, add the vitamins immediately prior to administration and complete administration within 24 hours.

Anaphylactic reactions have been reported following large intravenous doses of Thiamine. Urticaria and rash have also been associated with Zovia N. There have been very rare reports of anaphylactic reactions following IV injection/infusion with Zovia N over 1-4 minutes.

The use of this preparation has not been studied in human during pregnancy. This should be given to a pregnant woman only if clearly needed. The use of this product in lactating women is not recommended.

Anaphylactic reactions may occur in allergic subjects who are susceptible to Thiamine (Vitamin B1) and nicotinamide components of Zovia N. Mild allergic reactions such as sneezing or mild asthma are warning signs that further injection/infusion may give rise to anaphylactic shock. Due to glychocolic acid content, repeated and prolonged administration in patients with jaundice of hepatic origin or severe biochemical evidence of cholestatis requires careful monitoring of liver function. Also in the case of impaired kidney function, fat-soluble vitamin levels should be carefully monitored.

Accumulation of Vitamin A and Vitamin D may be occured with prolonged administration of high doses.